Lymphatic trafficking kinetics and near-infrared imaging using star polymer architectures with controlled anionic character.

Improving 3-D Imaging Breast Cancer Diagnosis Systems Using a New Method for Placement of Near-Infrared Sources and Detectors

The objective of this research was to improve 3-D imaging system by near-infrared light emission in breast tissue to achieve a more accurate diagnosis of tumor. The results of repeated experiments in this research have shown that with this imaging system, a more accurate diagnosis of abnormal area depends on the location of the sources and detectors. Therefore, an optimal location model has bee...

Evaluation of Reflection Optical Imaging Characteristics Using Fluorescence with Near Infrared Wavelength at Different Depths of Tissue Equivalent Phantom

Near infrared photoacoustic detection of sentinel lymph nodes with gold nanobeacons.

Detection of sentinel lymph node (SLN) using photoacoustic imaging is an emerging technique for noninvasive axillary staging of breast cancer. Due to the absence of intrinsic contrast inside the lymph nodes, exogenous contrast agents are used for photoacoustic detection. In this work, we have demonstrated near infrared detection of SLN with gold nanobeacons (GNBs) providing the photoacoustic co...

Mouse phenotyping with near-infrared fluorescence lymphatic imaging

We demonstrate the ability to non-invasively and quantitatively image lymphatic architecture and contractile function using dynamic near-infrared (NIR) fluorescence imaging with injection of indocyanine green in normal and transgenic mice. Unlike normal mice, which showed well defined lymphatic drainage patterns and orthograde propagation of contraction waves, we observed tortuous and mispatter...

In vivo visualization and quantification of collecting lymphatic vessel contractility using near-infrared imaging

Techniques to image lymphatic vessel function in either animal models or in the clinic are limited. In particular, imaging methods that can provide robust outcome measures for collecting lymphatic vessel function are sorely needed. In this study, we aimed to develop a method to visualize and quantify collecting lymphatic vessel function in mice, and to establish an in vivo system for evaluation...